Ibrahimovic’s Milan will play the Red Devils in the first leg of their last-16 clash on Thursday, March 11.
The 39-year-old has reportedly been ruled out of that match with an injury to his left thigh and he may even miss the second leg.
That is set to be played the following week, on Thursday, March 18.
Zlatan will be a big miss for Milan as he has scored an incredible 16 goals in just 21 games this season as he rapidly approaches his 40th birthday.
The Rossoneri are second in Serie A, four points behind rivals Internazionale.
Swedish superstar Zlatan left United in 2018 as he joined MLS for what we all thought was the swansong of his career.
It’s been a pretty lengthy swansong as he then headed back to Europe and rejoined Milan in January 2020.
He’s scored 27 goals in 40 appearances for the Italian club and surpassed the milestone of 500 club career goals.
At United, he scored 29 goals in 53 games and helped the Red Devils win the EFL Cup and Europa League.
“I feel sorry for the fans – if they’d seen me younger, they’d have seen a different lion,” he later told the Man United website.
“For the Premier League, it would have been dangerous, as I would have eaten them for breakfast; instead, I took them for lunch. But I came: they wanted me, I gave them me and I took over. Been there and done that.
“I gave as much as I could for as long as I could; when I got injured, I got support in a different way. They always stood behind me and my team-mates.
“They are special: everywhere I see red, I think about United. It will remain in history and my career; when I look back at my time with United, I will do it with a smile. I wish them all the best in the future.”